MOTS-C — Research Compound

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene. It represents a novel mechanism of mitochondrial- nuclear communication, linking cellular energy status to gene expression

Mechanism of Action
- Activates the AMPK pathway via inhibition of the folate-AICAR cycle.
- Translocates to the nucleus under metabolic stress to regulate gene expression through NRF2 binding.
- Targets skeletal muscle, liver, and adipose tissue with high tissue specificity.
- Restores metabolic flexibility and enhances mitochondrial function.

Pharmacokinetics
- Excellent subcutaneous bioavailability.
- Age-related plasma decline noted, suggesting therapeutic potential in aging and metabolic disorders.
- Investigational analog: CB4211, under study for hepatic steatosis.

Benefits May Include:

• Insulin Sensitivity: 30% increase in glucose infusion rate (Cell Metabolism, 2015)
• Exercise Mimetic: Boosts MOTS-C post-exercise to improve metabolic adaptations (Nature Communications, 2021)
• Cardiac Function: Enhanced systolic function and cardiac output (Cell Metabolism, 2018)
• Physical Performance: Increases lifespan and maximal performance in preclinical models
• Obesity Prevention: Improves energy expenditure and glucose utilization (PMC Review, 2022)
• Bone Preservation: Prevents bone loss and enhances mineral density
• Cognitive Benefits: Reduces pro-inflammatory cytokines, supports memory
• Anti-inflammatory: Increases IL-10, reduces systemic inflammation
• Autoimmune Diabetes Protection: Enhances regulatory T cell activity
• Thermogenesis: Activates brown adipose tissue and upregulates thermogenic genes

Specifications:

• Compound: MOTS-C
• Format: Research compound
• Use: Research use only