Semax — Research Compound

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH 4-10 fragment and modified with a stabilizing C-terminal Pro-Gly-Pro sequence. Originally developed in Russia, Semax is a nootropic and neuroprotective peptide with pronounced effects on cognition, neuroplasticity, and stress resilience, without influencing systemic cortisol levels

Mechanism of Action
— Melanocortin modulation Partial agonist/antagonist activity at MC4 and MC5 receptors; MC3 spared.
— BDNF/TrkB upregulation - Rapidly increases basal forebrain BDNF and TrkB phosphorylation, supporting neuroplasticity and cognitive enhancement
— Neurotransmitter modulation - Activates serotonergic and dopaminergic pathways, producing antidepressant and anxiolytic effects.
— Immunomodulation - Enhances chemokine and immunoglobulin expression while suppressing inflammatory markers in ischemic conditions.
— Enkephalinase inhibition - Reduces peptide degradation, indirectly supporting neuropeptide signaling.
— Calcium homeostasis - Modulates intracellular calcium signaling for neuroprotection.

Benefits May Include:

• Cognitive Enhancement: Improves memory, attention, learning, and mental clarity
• Neuroprotection: Protects neurons from ischemia, excitotoxicity, and neurodegeneration
• Stress Resilience: Produces anxiolytic and antidepressant-like effects
• Recovery Support: Accelerates post-stroke and post-injury brain repair
• Immune Support: Modulates immune activity in brain tissue, reducing inflammation
• Metal Toxicity Protection: Decreases neurotoxic effects from heavy metals
• Brain Circulation: Enhances microcirculation and oxygen delivery to neural tissue

Specifications:

• Compound: Semax 10mg
• Format: Research compound
• Use: Research use only